How alcohol withdrawal affects gene expression and brain function
RNA splicing regulation during alcohol withdrawal
This study looks at how drinking alcohol for a long time affects the brain's genes and can lead to feelings of anxiety and depression when someone stops drinking, with the goal of finding new ways to help people recover from alcohol use disorder.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10930890 on NIH RePORTER |
What this research studies
This research investigates how chronic alcohol exposure alters gene expression and RNA splicing in the brain, particularly during alcohol withdrawal. It focuses on understanding the molecular mechanisms that lead to negative emotional states, such as anxiety and depression, which can complicate recovery from alcohol use disorder. By studying changes in specific genes and their splicing factors in animal models, the research aims to uncover potential targets for therapeutic intervention. The findings could provide insights into how to better support individuals struggling with alcohol dependence.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use disorder or those experiencing withdrawal symptoms.
Not a fit: Patients who do not have a history of alcohol use or are not experiencing withdrawal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help individuals manage withdrawal symptoms and reduce the risk of relapse in alcohol use disorder.
How similar studies have performed: Previous research has shown promising results in understanding the effects of alcohol on gene expression, suggesting that this approach could yield valuable insights.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Carvalho, Luana Martins — Virginia Commonwealth University
- Study coordinator: Carvalho, Luana Martins
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.