How air pollution affects the immune system during pregnancy
Immune Tolerance Dysfunction in Pregnancy due to Ambient Air Pollution Exposure
This study looks at how air pollution might affect the immune health of pregnant women and their babies by checking blood samples to see if pollution changes how their immune systems work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10892038 on NIH RePORTER |
What this research studies
This research investigates the impact of ambient air pollution on the immune health of pregnant women. It focuses on how exposure to fine particulate matter (PM2.5) may lead to immune dysfunction during pregnancy and in the postpartum period. By analyzing previously collected blood samples from pregnant and non-pregnant women, the study aims to identify differences in immune cell function and identity related to pollution exposure. The findings could help understand the risks associated with air pollution for mothers and their babies.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women who have been exposed to varying levels of air pollution, particularly those in their second trimester.
Not a fit: Patients who are not pregnant or those who have not been exposed to significant levels of air pollution may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes for pregnant women and their children by identifying risks associated with air pollution exposure.
How similar studies have performed: While there have been epidemiological studies linking air pollution to adverse pregnancy outcomes, this specific approach examining immune dysfunction in pregnant women is relatively novel.
Where this research is happening
Boston, United States
- Harvard School of Public Health — Boston, United States (Active)
Researchers
- Principal investigator: Nadeau, Kari C. — Harvard School of Public Health
- Study coordinator: Nadeau, Kari C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.