How aging affects muscle function and performance
Protein modification and the aging phenotype of human skeletal muscle
This study looks at how aging affects muscle strength and function, especially why older adults lose muscle mass and power, to help find ways to keep muscles healthy as we get older.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project ID | NIH-10792945 on NIH RePORTER |
What this research studies
This research investigates the changes in muscle function and performance as people age, focusing on the mechanisms behind muscle atrophy and the decline in contractile power. It aims to understand how these changes contribute to sarcopenia, a condition characterized by the loss of muscle mass and strength in older adults. By examining the relationship between muscle size, contractile function, and fatigue during physical activities, the study seeks to identify unique factors that influence muscle aging. The findings could lead to better strategies for maintaining muscle health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 21 and above who are experiencing age-related muscle decline or sarcopenia.
Not a fit: Patients who are younger than 21 or those without any signs of muscle decline or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved interventions for preventing muscle loss and enhancing physical function in older adults.
How similar studies have performed: Previous research has shown promising results in understanding muscle aging and its effects on physical function, indicating that this approach has potential for significant insights.
Where this research is happening
Eugene, United States
- University of Oregon — Eugene, United States (Active)
Researchers
- Principal investigator: Callahan, Damien Mark — University of Oregon
- Study coordinator: Callahan, Damien Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.