How aging affects lung cells and cancer development
Progenitor cell states contributing to aging and lung cancer
['FUNDING_U01'] · HARVARD MEDICAL SCHOOL · NIH-11065572
This study is looking at how getting older affects certain lung cells and their connection to lung cancer, with the hope of finding new ways to prevent or treat the disease for people as they age.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11065572 on ClinicalTrials.gov |
What this research studies
This research investigates how aging influences lung progenitor cells and their role in lung cancer development. It focuses on understanding the metabolic and epigenetic changes that occur in these cells as people age, which may lead to an increased risk of lung cancer. By using advanced technologies, the study aims to map these changes at a cellular level and develop new models to better understand the initiation of lung cancer. Patients may benefit from insights that could lead to new prevention or treatment strategies for lung cancer linked to aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those at risk for lung cancer due to age-related changes.
Not a fit: Patients who are younger than 21 or do not have risk factors for lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating lung cancer in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between aging and cancer, making this approach both relevant and potentially impactful.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAIGIS, MARCIA — HARVARD MEDICAL SCHOOL
- Study coordinator: HAIGIS, MARCIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brain Cancer, Breast Cancer, Cancer Cause, Cancer Etiology, Cancers