How aging affects blood flow in the heart
Metabolic regulation of myocardial perfusion in the aging heart
This study looks at how getting older affects the heart's ability to adjust blood flow when you’re active, and it aims to find ways to help improve heart function for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-10979015 on NIH RePORTER |
What this research studies
This research investigates how aging impacts the heart's ability to regulate blood flow according to its metabolic needs. It focuses on the mechanisms that lead to decreased blood perfusion in the heart as people age, particularly during times of increased physical activity. By examining the cellular signaling involved in this process, the study aims to identify potential interventions that could improve heart function in older adults. The research employs advanced techniques to measure changes in blood flow and metabolic signals in heart cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing heart-related issues or those at risk of cardiovascular diseases.
Not a fit: Patients who are younger and do not have any cardiovascular risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart conditions in older adults, enhancing their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between aging and heart function, indicating that this approach has potential for success.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Hill, Bradford Guy — University of Louisville
- Study coordinator: Hill, Bradford Guy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.