How aging affects blood flow in the heart
Official title: Metabolic regulation of myocardial perfusion in the aging heart
Funded at University of Louisville · NIH-10979015 · Data updated 2026-11-12
This study looks at how getting older affects the heart's ability to adjust blood flow when you’re active, and it aims to find ways to help improve heart function for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $508,368 |
| NIH project number | 1R01AG084688-01A1 |
| Project ID | NIH-10979015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing heart-related issues or those at risk of cardiovascular diseases.
✕Less likely to help
Patients who are younger and do not have any cardiovascular risk factors may not benefit from this research.
What this research studies
This research investigates how aging impacts the heart's ability to regulate blood flow according to its metabolic needs. It focuses on the mechanisms that lead to decreased blood perfusion in the heart as people age, particularly during times of increased physical activity. By examining the cellular signaling involved in this process, the study aims to identify potential interventions that could improve heart function in older adults. The research employs advanced techniques to measure changes in blood flow and metabolic signals in heart cells.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart conditions in older adults, enhancing their quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between aging and heart function, indicating that this approach has potential for success.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Hill, Bradford Guy — University of Louisville
- Study coordinator: Hill, Bradford Guy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.