How a specific RNA variant affects inflammation and immune response
Official title: Regulation of the Inflammasome by Gasdermin D mRNA Chimerism
Funded at Harvard Medical School · NIH-11068769 · Data updated 2026-11-12
This study is looking at a special type of RNA that might help control inflammation and immune responses, which could be important for people dealing with diseases caused by too much inflammation.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $43,203 |
| NIH project number | 1F31AI181475-01A1 |
| Project ID | NIH-11068769 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from autoinflammatory diseases or conditions associated with excessive inflammation.
✕Less likely to help
Patients with non-inflammatory conditions or those not affected by autoinflammatory diseases may not benefit from this research.
What this research studies
This research investigates the role of a unique RNA variant formed by the fusion of two genes in regulating inflammation and immune responses. By studying how this chimeric mRNA influences the activation of the inflammasome, the research aims to understand its impact on the release of inflammatory signals and cell death. The approach involves using RNA interference techniques to selectively reduce the expression of this RNA variant in immune cells, allowing researchers to observe changes in inflammatory responses. This could lead to insights into how excessive inflammation contributes to various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing autoinflammatory diseases and improving immune responses.
How similar studies have gone: Previous research has shown promising results in understanding RNA processing and its implications for immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Venezia, Olivia L. — Harvard Medical School
- Study coordinator: Venezia, Olivia L.
Related research
Other NIH-funded projects on the same topics.
-
Comparing End-of-Life Care for Older Adults Across Richer Countries
Aims to understand how end-of-life care for older adults with serious illnesses differs in the US compared with other high-income countries.
-
Comparing End-of-Life Care for Older Adults Across Rich Countries
A study compares how end-of-life care is handled for older adults in the US and other high-income countries to identify what might improve care here.
-
Comparing End-of-Life Care for Older Adults in Rich Countries
A large study from Harvard Medical School compares how older adults near the end of life are cared for in the US and other top-income countries to understand differences and improve care.
-
Comparing End-of-Life Care for Older Adults Across Rich Countries
A study using international data to understand how end-of-life care for older adults with poor prognoses differs across five high‑income countries.
-
Comparing End-of-Life Care for Older Adults Across Rich Countries
A research project compares how older adults with serious illnesses receive end-of-life care in the US and other high-income countries to find ways to improve care in the United States.
-
Comparing End-of-Life Care for Older Adults Across Rich Countries
A project compares how older adults near the end of life are cared for in the U.S. and other high-income countries to identify ways to improve care and reduce wasteful spending.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.