How a specific protein modification affects the body's response to viral infections
Regulation of RIG-I signaling and viral immune evasion by ufmylation
This study is looking at how a special process called ufmylation affects how our immune system fights off RNA viruses, with the hope of finding better treatments for viral infections that could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11097346 on NIH RePORTER |
What this research studies
This research investigates how ufmylation, a type of protein modification, influences the body's immune response to RNA viruses. It focuses on the RIG-I signaling pathway, which is crucial for producing interferons that help fight viral infections. By understanding the role of ufmylation in regulating this pathway, the research aims to uncover new mechanisms of viral immune evasion and improve antiviral therapies. Patients may benefit from insights gained that could lead to more effective treatments for viral infections.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with viral infections or those at risk of developing autoimmune conditions related to viral responses.
Not a fit: Patients with non-viral related conditions or those not affected by viral infections may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved antiviral therapies that enhance the body's ability to fight viral infections.
How similar studies have performed: Other research has shown promising results in understanding immune responses to viral infections, making this approach both relevant and potentially impactful.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Horner, Stacy Michelle — Duke University
- Study coordinator: Horner, Stacy Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.