How a specific protein modification affects cell division and cancer development
Official title: Temporal-spatial control of mitotic regulators by polySUMOylation
Funded at Florida State University · NIH-11097395 · Data updated 2026-11-12
This study is looking at how a special process that changes proteins helps control cell division and DNA repair in yeast, which could help us understand cancer better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $27,588 |
| NIH project number | 3R01GM151447-02S1 |
| Project ID | NIH-11097395 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers associated with genomic instability or those interested in the biological mechanisms of cancer.
✕Less likely to help
Patients with stable cancers that do not involve genomic instability may not benefit from this research.
What this research studies
This research investigates the role of polySUMOylation, a process that modifies proteins, in regulating key factors involved in cell division and DNA repair. By studying this mechanism in yeast cells, the researchers aim to understand how it influences the relocation of important proteins during the cell cycle. The findings could provide insights into how disruptions in these processes contribute to cancer and genome instability. Ultimately, the goal is to uncover fundamental knowledge that could lead to new treatment strategies for cancer.
Why it matters
Potential benefit: If successful, this research could lead to new approaches for treating cancers linked to genome instability.
How similar studies have gone: While the specific approach of studying polySUMOylation in this context is novel, similar research has shown promise in understanding cellular mechanisms related to cancer.
Where this research is happening
-
Florida State University
Tallahassee, United States Active
Researchers
- Principal investigator: Wang, Yanchang — Florida State University
- Study coordinator: Wang, Yanchang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.