How a specific protein modification affects cell division and cancer development
Official title: Temporal-spatial control of mitotic regulators by polySUMOylation
Funded at Florida State University · NIH-10914244 · Data updated 2026-11-12
This study is looking at how a special process that changes proteins helps control cell division and DNA repair, using yeast cells to learn more about how these changes might affect cancer development and treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $330,839 |
| NIH project number | 5R01GM151447-02 |
| Project ID | NIH-10914244 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers linked to genomic instability or those at high risk for such conditions.
✕Less likely to help
Patients with stable cancers that do not involve genomic instability may not benefit from this research.
What this research studies
This research investigates the role of polySUMOylation, a process that modifies proteins, in regulating key factors involved in cell division and DNA repair. By studying how this modification affects the relocation of important proteins during the cell cycle, the research aims to uncover mechanisms that maintain genome stability. The approach involves using yeast cells as a model to observe these processes, which could provide insights into cancer development and potential treatment strategies. The findings could lead to a better understanding of how disruptions in these processes contribute to diseases like cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers associated with genome instability.
How similar studies have gone: Other research has shown promising results in understanding protein modifications and their roles in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Florida State University
Tallahassee, United States Active
Researchers
- Principal investigator: Wang, Yanchang — Florida State University
- Study coordinator: Wang, Yanchang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.