How a specific protein helps lung cells respond to injury from pneumonia
TRPV4 Regulates Mechanosensitive Macrophage Functions in Lung Injury
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11018641
This study is looking at how a protein called TRPV4 helps immune cells in the lungs fight off infections like bacterial pneumonia, with the hope of finding better treatments for people suffering from serious breathing problems like acute respiratory distress syndrome (ARDS).
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11018641 on ClinicalTrials.gov |
What this research studies
This research investigates how the TRPV4 protein influences the behavior of macrophages, which are immune cells that play a crucial role in lung injury caused by bacterial pneumonia. By understanding the mechanisms that allow TRPV4 to enhance the lung's defense against infections, the study aims to identify new therapeutic targets for treating acute respiratory distress syndrome (ARDS). The research employs in vivo models to explore the signaling pathways involved in macrophage function during lung injury. Patients may benefit from insights gained that could lead to improved treatments for ARDS.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing acute respiratory distress syndrome, particularly those with pneumonia-related lung injury.
Not a fit: Patients with chronic lung diseases unrelated to pneumonia may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve outcomes for patients suffering from acute respiratory distress syndrome.
How similar studies have performed: Previous research has shown promising results in understanding macrophage functions in lung injury, suggesting that this approach could yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHERAGA, RACHEL GREENBERG — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: SCHERAGA, RACHEL GREENBERG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome