How a specific protein complex regulates the body's antiviral responses
Regulation of innate antiviral responses by the DNA-binding transcriptional repressor complex CIC-ATXN1/L
This study is looking at how a specific protein complex helps your body fight off viruses by controlling important immune signals, and it's for anyone interested in understanding how our immune system works to prevent infections and autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10923583 on NIH RePORTER |
What this research studies
This research investigates the role of the CIC-ATXN1/L protein complex in controlling the body's innate antiviral responses, particularly focusing on how it regulates the expression of interferon and interferon-stimulated genes (ISGs). By utilizing advanced techniques like CRISPR/Cas9 screening, the study aims to identify how the knockout of the CIC protein affects the body's ability to respond to viral infections. The research seeks to understand the mechanisms that maintain immune system balance and prevent diseases linked to improper immune responses, such as chronic infections and autoimmune disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic viral infections or autoimmune diseases that may benefit from enhanced antiviral responses.
Not a fit: Patients with acute viral infections or those not affected by immune regulation issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing antiviral responses in patients, potentially improving outcomes for those with viral infections.
How similar studies have performed: Other research has shown success in manipulating immune responses through similar genetic approaches, indicating potential for breakthroughs in this area.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Manicassamy, Balaji — University of Iowa
- Study coordinator: Manicassamy, Balaji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.