How a specific protein complex regulates the body's antiviral responses
Regulation of innate antiviral responses by the DNA-binding transcriptional repressor complex CIC-ATXN1/L
This study is looking at how a specific protein helps your body fight off viruses, and it aims to find ways to boost your immune response, which could lead to better treatments for viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10889154 on NIH RePORTER |
What this research studies
This research investigates the role of a protein complex in controlling the body's innate immune response to viral infections. By using advanced techniques like CRISPR/Cas9 screening, the study aims to identify how the Capicua (CIC) protein influences the expression of interferon and interferon-stimulated genes, which are crucial for fighting off viruses. The research will explore how manipulating this protein complex could enhance the body's ability to respond to viral threats, potentially leading to new therapeutic strategies for viral infections and related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic viral infections or autoimmune diseases who may benefit from enhanced antiviral responses.
Not a fit: Patients with acute viral infections that do not involve the immune response mechanisms being studied may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for viral infections and conditions exacerbated by immune response dysregulation, such as chronic viral infections and autoimmune diseases.
How similar studies have performed: Other research has shown promising results in manipulating immune responses through similar genetic approaches, indicating potential for success in this area.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Manicassamy, Balaji — University of Iowa
- Study coordinator: Manicassamy, Balaji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.