How a specific mitochondrial carrier affects liver function in diabetes
Official title: Regulation of Hepatic Fuel Fluxes by the Mitochondrial Dicarboxylate Carrier
Funded at University of Iowa · NIH-11004110 · Data updated 2026-11-12
This study is looking at how a specific protein in the liver helps control blood sugar levels, especially for people with type 2 diabetes, to find new ways to improve diabetes management.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | December 26, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $482,871 |
| NIH project number | 5R01DK138664-02 |
| Project ID | NIH-11004110 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes who are interested in understanding the underlying metabolic processes affecting their condition.
✕Less likely to help
Patients with type 1 diabetes or those without any form of diabetes may not benefit from this research.
What this research studies
This research investigates the role of the mitochondrial dicarboxylate carrier (DiC) in regulating liver processes that are crucial for managing blood sugar levels, particularly in type 2 diabetes (T2D). By examining how the DiC influences gluconeogenesis, the process by which the liver produces glucose, the study aims to uncover the mechanisms that lead to dysregulation in T2D. The research employs advanced techniques including mouse genetics and cell culture to explore how the DiC's function changes in diabetic conditions. Understanding these mechanisms could provide insights into potential therapeutic targets for managing T2D.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing type 2 diabetes by targeting liver metabolism.
How similar studies have gone: While the specific focus on the mitochondrial dicarboxylate carrier is relatively novel, previous research has shown success in understanding metabolic pathways in diabetes, suggesting potential for impactful findings.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Taylor, Eric B — University of Iowa
- Study coordinator: Taylor, Eric B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.