How a specific blood cell disorder affects kidney disease progression
Impact of Clonal Hematopoiesis on the Progression of Kidney Disease
This study is looking at how a common blood cell condition that often affects older adults might influence the worsening of kidney disease, helping us understand new factors that could impact kidney health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11121777 on NIH RePORTER |
What this research studies
This research investigates the impact of clonal hematopoiesis of indeterminate potential (CHIP) on the progression of kidney disease, particularly in older adults. It explores how this blood cell disorder, which becomes more common with age, may contribute to kidney inflammation and fibrosis, leading to chronic kidney disease (CKD). The study involves examining biological mechanisms and potential links between CHIP and kidney health, using both human samples and animal models to understand the underlying processes. By identifying these connections, the research aims to uncover new risk factors for CKD progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 65 years of age, who may be experiencing or at risk for chronic kidney disease.
Not a fit: Patients under 21 years old or those without any signs of kidney disease or clonal hematopoiesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing the progression of kidney disease in older adults.
How similar studies have performed: Other research has indicated potential links between clonal hematopoiesis and various health conditions, suggesting that this approach may yield valuable insights into kidney disease progression.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Robinson-Cohen, Cassianne — Vanderbilt University Medical Center
- Study coordinator: Robinson-Cohen, Cassianne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.