How a protein helps manage DNA processes
Official title: Coordination of DNA Metabolism by Replication Protein A
Funded at Saint Louis University · NIH-11065527 · Data updated 2026-11-12
This study is looking at how a protein called RPA helps keep our DNA safe and working properly, which could lead to better treatments for DNA-related diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $546,612 |
| NIH project number | 5R35GM149320-03 |
| Project ID | NIH-11065527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic predispositions to DNA repair deficiencies or related conditions, such as certain cancers.
✕Less likely to help
Patients with conditions unrelated to DNA metabolism or those not experiencing DNA repair issues may not benefit from this research.
What this research studies
This research investigates the role of Replication Protein A (RPA) in managing various DNA processes such as replication, repair, and recombination. It focuses on how RPA interacts with single-stranded DNA (ssDNA) and other proteins to protect and regulate access to the DNA. By understanding these interactions, the research aims to uncover the mechanisms that ensure genomic integrity and proper DNA function. Patients may benefit from insights gained into DNA-related diseases, including cancer, as the findings could lead to improved therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of DNA maintenance, potentially leading to better treatments for DNA-related diseases.
How similar studies have gone: Previous research has shown success in understanding DNA repair mechanisms, suggesting that this approach could yield valuable insights as well.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Antony, Edwin — Saint Louis University
- Study coordinator: Antony, Edwin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.