How a protein called Vps33B affects immune responses and inflammation
Regulation of TLR signaling, Inflammation and Antigen Presentation by VPS33B
This study is looking at a protein called Vps33B to see how it helps our immune system respond to infections, which could lead to better treatments for infections and inflammation, and it's being tested in mice and fruit flies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10864059 on NIH RePORTER |
What this research studies
This research investigates the role of a protein named Vps33B in regulating immune responses, particularly how it influences the signaling pathways of Toll-like receptors (TLRs) that detect infections. By studying how Vps33B affects the endocytosis of TLRs and the subsequent inflammatory responses in immune cells, the research aims to uncover mechanisms that could lead to better understanding and treatment of various infections and inflammatory conditions. The approach involves both mouse models and Drosophila to explore the effects of Vps33B on immune signaling and phagocytosis.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with immune system disorders or those susceptible to bacterial infections.
Not a fit: Patients with non-infectious conditions or those not affected by immune system dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses against infections and improving treatments for inflammatory diseases.
How similar studies have performed: Previous research has shown promising results in understanding TLR signaling and its implications for immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Pasare, Chandrashekhar — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Pasare, Chandrashekhar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.