How a protein called netrin-1 guides cell movement during development
Netrin Glycosylation Influences Chemotaxis and Haptotaxis
This study is looking at a special protein called netrin-1 to see how it helps guide cells during development, which is important for making sure organs grow properly, and it aims to create mouse models to better understand how changes in this protein can affect cell movement.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10828904 on NIH RePORTER |
What this research studies
This research investigates the role of netrin-1, a glycoprotein, in guiding cell movement during development. It aims to understand how different forms of netrin-1 can act as both long-range and local cues for cells, influencing their migration in either an attractive or repulsive manner. By purifying and characterizing these forms, the researchers will explore how glycosylation affects the behavior of netrin-1, which is crucial for the proper development of various organ systems. The ultimate goal is to create mouse models that can help manipulate netrin glycosylation for further studies.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with developmental disorders or conditions that involve abnormal cell migration.
Not a fit: Patients with conditions unrelated to developmental processes or cell migration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into developmental processes and potential therapeutic strategies for conditions related to cell migration.
How similar studies have performed: Other research has shown success in understanding the roles of glycoproteins in cell movement, making this approach promising yet still exploring new aspects of netrin-1.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Gupton, Stephanie — Univ of North Carolina Chapel Hill
- Study coordinator: Gupton, Stephanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.