How a protein called ABCB7 affects blood cell production in autoimmune conditions
Cell-extrinsic emergency myelopoiesis regulated by ABCB7
This project explores how a specific protein, ABCB7, in immune cells might lead to problems with blood cell production, especially in people with autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11105957 on NIH RePORTER |
What this research studies
Our bodies constantly make new blood cells, a process called myelopoiesis, which can sometimes go wrong. This project looks at how issues with a protein called ABCB7 in certain immune cells (B cells) can cause problems with making blood cells. We've seen in early work that when ABCB7 is missing in B cells, it can lead to too many myeloid cells and not enough red blood cells, causing anemia. Understanding this process could help us learn why people with chronic inflammation or autoimmune diseases sometimes develop blood disorders.
Who could benefit from this research
Good fit: Patients with autoimmune diseases, chronic inflammation, or those at risk for myelodysplastic syndromes or anemia might eventually benefit from this fundamental research.
Not a fit: Patients without conditions related to autoimmune diseases, chronic inflammation, or blood cell production disorders may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to understand and potentially treat blood disorders like myelodysplastic syndromes and anemia, especially in patients with autoimmune conditions.
How similar studies have performed: This research builds on preliminary data showing a novel mechanism for cell-extrinsic myelopoiesis, suggesting a new area of investigation.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Shapiro, Virginia Smith — Mayo Clinic Rochester
- Study coordinator: Shapiro, Virginia Smith
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.