How a protein affects the growth of lymphatic vessels in heart disease
Regulation of Lymphangiogenesis by Thrombospondin 1
This study is looking at how a protein called thrombospondin-1 affects the growth of lymphatic vessels in arteries with atherosclerosis, which could help improve cholesterol removal and reduce heart problems for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10761700 on NIH RePORTER |
What this research studies
This research investigates the role of thrombospondin-1 (TSP1) in the formation of lymphatic vessels within arteries affected by atherosclerosis, a condition that leads to significant cardiovascular issues. The study aims to understand how TSP1 influences lymphangiogenesis, which is crucial for removing cholesterol and inflammatory cells from atherosclerotic lesions. By examining the effects of TSP1 on lymphatic endothelial cells, the research seeks to uncover potential therapeutic targets that could improve cholesterol transport and reduce atherosclerosis progression. Patients may benefit from insights gained about how to enhance lymphatic function in cardiovascular disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with atherosclerotic cardiovascular disease or those at high risk for developing this condition.
Not a fit: Patients without atherosclerosis or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lymphatic function and reduce the severity of atherosclerosis, potentially lowering cardiovascular disease risk.
How similar studies have performed: Previous research has shown that targeting lymphatic function can influence atherosclerosis, suggesting that this approach may yield valuable insights.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Singla, Bhupesh — University of Tennessee Health Sci Ctr
- Study coordinator: Singla, Bhupesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.