How a protein affects immune responses to bacterial infections
Official title: Modulation of neutrophil-endothelial interactions by ADAM10
Funded at Washington University · NIH-11039663 · Data updated 2026-11-12
This study is looking at how a protein called ADAM10 affects the way immune cells interact with blood vessel cells during infections caused by Staphylococcus aureus, with the hope of finding new ways to help the body fight these infections better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | January 23, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $226,253 |
| NIH project number | 1R21AI188434-01 |
| Project ID | NIH-11039663 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include both children and adults who are at risk of or suffering from Staphylococcus aureus infections.
✕Less likely to help
Patients with infections caused by other types of bacteria may not benefit from this research.
What this research studies
This research investigates how the protein ADAM10 influences the interactions between neutrophils and endothelial cells during Staphylococcus aureus infections. By understanding the mechanisms of how this protein modulates immune responses, the research aims to identify potential therapeutic targets that could enhance the body's ability to fight off these infections. The study will involve examining the effects of ADAM10 on immune cell behavior and its role in the injury caused by the bacteria. Patients may benefit from insights that could lead to improved treatments for infections caused by Staphylococcus aureus.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating serious bacterial infections.
How similar studies have gone: Previous research has shown promise in targeting similar mechanisms in bacterial infections, suggesting a potential for success in this approach.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Bubeck Wardenburg, Juliane — Washington University
- Study coordinator: Bubeck Wardenburg, Juliane
Related research
Other NIH-funded projects on the same topics.
-
Using MRI to measure brain oxygen levels as an early sign of small vessel disease in the brain
This study is looking at how measuring oxygen levels in the brain with MRI can help spot early signs of small vessel disease, which is linked to memory problems and dementia, especially Alzheimer's, so if you're at risk due to age or high blood pressure, you might be able to participate in MRI scans to learn more about
-
Advanced Methods & Modeling for Better Patient Care
A funding opportunity focused on developing new modeling methods to improve health care for patients through better data use and analytics.
-
Advanced methods and modeling for health research at Washington University
A health research grant at Washington University funds new modeling methods to support future patient-focused studies.
-
Center for Research in Emerging Infectious Diseases: Epidemiology, Surveillance and Pathogenesis
A NIH program will study and monitor emerging viruses from the Midwest U.S. and three Asian sites to understand how they spread and affect people.
-
How Poverty and the Environment Affect Heart Disease in Haiti and Beyond
This grant studies how poverty-related factors like food insecurity, stress, and pollution contribute to heart disease and aims to follow a large group of adults to better understand and prevent the disease.
-
Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.