How a protein affects immune responses to bacterial infections
Modulation of neutrophil-endothelial interactions by ADAM10
This study is looking at how a protein called ADAM10 affects the way immune cells interact with blood vessel cells during infections caused by Staphylococcus aureus, with the hope of finding new ways to help the body fight these infections better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11039663 on NIH RePORTER |
What this research studies
This research investigates how the protein ADAM10 influences the interactions between neutrophils and endothelial cells during Staphylococcus aureus infections. By understanding the mechanisms of how this protein modulates immune responses, the research aims to identify potential therapeutic targets that could enhance the body's ability to fight off these infections. The study will involve examining the effects of ADAM10 on immune cell behavior and its role in the injury caused by the bacteria. Patients may benefit from insights that could lead to improved treatments for infections caused by Staphylococcus aureus.
Who could benefit from this research
Good fit: Ideal candidates for this research include both children and adults who are at risk of or suffering from Staphylococcus aureus infections.
Not a fit: Patients with infections caused by other types of bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating serious bacterial infections.
How similar studies have performed: Previous research has shown promise in targeting similar mechanisms in bacterial infections, suggesting a potential for success in this approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Bubeck Wardenburg, Juliane — Washington University
- Study coordinator: Bubeck Wardenburg, Juliane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.