How a protein affects immune cell function and fat metabolism in autoimmune diseases
Apolipoprotein E governs lymph node stromal cell function and lipid metabolism during autoimmunity
This study is looking at how a protein called apoE affects immune cells and fat processing in people with autoimmune diseases, hoping to find new ways to help treat these conditions and prevent heart problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11033258 on NIH RePORTER |
What this research studies
This research investigates the role of apolipoprotein E (apoE) in regulating immune cell functions and lipid metabolism in patients with autoimmune diseases. It focuses on lymph node stromal cells, which are crucial for maintaining immune balance and responding to infections. By understanding how these cells interact with lipids and immune responses, the research aims to uncover new therapeutic targets for treating autoimmune conditions and preventing related cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autoimmune diseases who may also be experiencing lipid metabolism issues.
Not a fit: Patients without autoimmune diseases or those not experiencing lipid metabolism disruptions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autoimmune diseases and strategies to prevent cardiovascular complications in affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the links between lipid metabolism and immune regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Poholek, Catherine — University of Pittsburgh at Pittsburgh
- Study coordinator: Poholek, Catherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.