How a new signaling process affects kidney function
Novel Regulation of Renal Function by S-Nitrosylation
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10996185
This study is looking at how a special protein system in the kidneys can help them heal after an injury, like acute kidney injury (AKI), and aims to find ways to boost this healing process to improve kidney function for people dealing with AKI.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10996185 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a novel protein signaling system in the kidneys, specifically focusing on how S-nitrosylation, a process involving nitric oxide, can influence kidney repair after acute kidney injury (AKI). The study aims to understand how enhancing this signaling can promote kidney recovery and prevent long-term damage. By examining the effects of specific proteins involved in this process, the research seeks to identify potential therapeutic targets for improving kidney function in patients suffering from AKI.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced acute kidney injury, particularly those hospitalized or in intensive care.
Not a fit: Patients with chronic kidney disease or those who have not experienced acute kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance kidney repair and improve outcomes for patients with acute kidney injury.
How similar studies have performed: While the specific approach of targeting S-nitrosylation in kidney repair is novel, similar signaling mechanisms have shown promise in other organ repair processes.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, HUALIN — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: ZHOU, HUALIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute kidney injury