How a chemical pollutant affects immune cell behavior and autoimmune diseases
Epigenetic modulation of CD4+ T cell differentiation and autoimmunity by trichloroethylene
This study is looking at how a common environmental pollutant called trichloroethylene (TCE) affects important immune cells that help protect our bodies, with the goal of understanding how it might contribute to autoimmune diseases, which could help people with these conditions learn more about what triggers their illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project ID | NIH-11003332 on NIH RePORTER |
What this research studies
This research investigates the effects of trichloroethylene (TCE), an environmental pollutant, on the differentiation of CD4+ T cells, which are crucial for immune responses. By examining how TCE and its metabolite influence the development of these immune cells, the study aims to uncover mechanisms that may lead to autoimmune diseases. The research involves both laboratory experiments with mouse models and genetic analysis to understand how these processes differ based on genetic susceptibility and sex. Patients with autoimmune conditions may benefit from insights gained about the environmental triggers of their diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals with autoimmune diseases or those at risk due to environmental exposures.
Not a fit: Patients with autoimmune diseases not related to environmental factors or those who do not have a genetic predisposition may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new strategies for preventing or treating autoimmune diseases linked to environmental factors.
How similar studies have performed: Previous research has shown that environmental pollutants can influence immune responses, suggesting that this approach may yield valuable insights into autoimmune disease mechanisms.
Where this research is happening
Albuquerque, United States
- University of New Mexico Health Scis Ctr — Albuquerque, United States (Active)
Researchers
- Principal investigator: Blossom, Sarah J — University of New Mexico Health Scis Ctr
- Study coordinator: Blossom, Sarah J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.