How a bacterium manipulates host cell structures to evade the immune system
The interface between L. pneumophila manipulation of host endoplasmic reticulum and innate immune subterfuge
This study looks at how the Legionella bacteria grow inside our cells and hide from our immune system, with the goal of finding new ways to help people fight infections caused by this germ.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10767265 on NIH RePORTER |
What this research studies
This research investigates how the bacterium Legionella pneumophila grows inside host cells by creating specialized compartments that protect it from the immune system. It focuses on the role of specific bacterial proteins in manipulating the host's endoplasmic reticulum to facilitate this growth and evade immune detection. By understanding these mechanisms, the research aims to uncover potential targets for therapeutic intervention. Patients may benefit from insights gained about how to combat infections caused by this bacterium.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals at risk for Legionella infections, such as those with weakened immune systems or underlying respiratory conditions.
Not a fit: Patients who are not at risk for Legionella infections or who do not have any immune system deficiencies may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections caused by Legionella pneumophila.
How similar studies have performed: Other research has shown success in understanding bacterial manipulation of host cells, indicating that this approach has potential for significant findings.
Where this research is happening
Boston, United States
- Tufts University Boston — Boston, United States (Active)
Researchers
- Principal investigator: Isberg, Ralph R. — Tufts University Boston
- Study coordinator: Isberg, Ralph R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.