Host Immune Response Core for Gonorrhea Interventions
Official title: Core B - Functional Immunology Core (CIIG)
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-11394883 · Data updated 2026-11-12
A central core will provide standardized immune tests and analyses to support vaccine, therapy, and diagnostic development against gonorrhea.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | August 12, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $813,991 |
| NIH project number | 5U19AI189178-02 |
| Project ID | NIH-11394883 on NIH RePORTER |
Who could benefit from this research
✓Could help
Researchers and institutions conducting CIIG projects with gonorrhea-targeted vaccines or therapies; eventual clinical trial participants may benefit from validated assays.
✕Less likely to help
Direct patient benefit is unlikely for individuals not involved in CIIG projects or future trials.
What this research studies
This NIH grant funds a centralized core that offers high-throughput tests to measure antibodies, immune cell responses, and biomarkers in serum and genital tissues after immunization or infection. It will develop and validate standardized assays for both pre-clinical and clinical studies to help move products toward licensure. The work aims to identify correlates and mechanisms of protection against gonorrhea so future treatments and vaccines can be evaluated consistently. Researchers will profile humoral and cellular responses, including antibody avidity and mucosal immunity, and will characterize tissue immunophenography and biomarker patterns. The core supports other CIIG projects by providing shared immune-monitoring capabilities.
Why it matters
Potential benefit: Could accelerate development of effective vaccines and therapies against gonorrhea by providing reliable, standardized immune measurements.
How similar studies have gone: Prior centralized immune-monitoring cores have enabled consistent biomarker work and correlates of protection in infectious disease vaccine programs.
Where this research is happening
-
Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Criss, Alison K — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Criss, Alison K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.