Host and parasite factors shaping P. vivax invasion of red blood cells
Official title: Host and parasite factors influencing P. vivax RBC invasion and asexual development
Funded at University of Maryland Baltimore · NIH-11528294 · Data updated 2026-11-12
Researchers will study how human blood cells and the parasite itself interact in people with vivax malaria to uncover factors that influence infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 8, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $154,170 |
| NIH project number | 3R01AI165483-05S1 |
| Project ID | NIH-11528294 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with Plasmodium vivax infection or at risk of infection, particularly from Cambodia, may be compatible after screening.
✕Less likely to help
Individuals not affected by vivax malaria or without related samples may not directly benefit.
What this research studies
This project uses blood samples from Cambodian patients to explore how red blood cell differences and the immune response affect how Plasmodium vivax invades cells and grows. It will apply advanced transcriptomic methods to link host and parasite factors to malaria biology. The goal is to build knowledge that could guide better vaccines and therapies against vivax malaria.
Why it matters
Potential benefit: If successful, findings could lead to improved vaccines or treatments for vivax malaria and help accelerate elimination efforts.
How similar studies have gone: Prior transcriptomic studies have revealed host–parasite interactions in malaria, supporting potential for meaningful insights here.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Serre, David — University of Maryland Baltimore
- Study coordinator: Serre, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.