Home self-sampling to improve detection of anal precancers
Self-sampling to Optimize Anal Lesion Outcomes (SOLO)
This program offers people at higher risk for anal cancer home self-sampling kits plus education to help them complete follow-up cytology and high-resolution anoscopy appointments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11291272 on NIH RePORTER |
What this research studies
You would be invited to join one of two groups as part of a randomized trial enrolling 572 people in Chicago, Houston, and Milwaukee. If assigned to the home-kit group, you'll receive a mailed self-sampling kit, educational materials, and options for in-clinic self-sampling and high-resolution anoscopy (HRA) if needed. If assigned to the comparison group, you'll receive education and the usual clinic-based provider sampling and HRA pathway. The study records whether people attend scheduled cytology and HRA appointments to see which approach improves follow-up and detection of precancerous lesions.
Who could benefit from this research
Good fit: Ideal candidates are people at higher risk for anal cancer (for example those with known HPV exposure or other established risk factors) who are eligible for anal screening and able to attend clinics in the study cities.
Not a fit: People at low risk for anal cancer, those not eligible for anal screening, or those unwilling/unable to use home kits or attend follow-up clinics may not receive benefit from this program.
Why it matters
Potential benefit: If successful, this could increase screening participation and lead to earlier detection and treatment of anal precancers, lowering the risk of anal cancer.
How similar studies have performed: Prior work found that home-based self-sampling increased screening participation by more than 50% compared with clinic screening, so this trial builds on promising but not yet definitive evidence.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Nyitray, Alan Gaspar — Medical College of Wisconsin
- Study coordinator: Nyitray, Alan Gaspar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.