High-speed 3D brain imaging in moving mice using implantable technology
Implantable 3D fluorescence imaging with high-speed, addressable laser scanning in moving mice
This study is working on a tiny, implantable microscope that can take fast, 3D pictures of brain activity in moving mice, which could help scientists learn more about how the brain works and lead to better treatments for neurological conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10614795 on NIH RePORTER |
What this research studies
This research aims to develop a miniature, implantable microscope that can perform high-speed, three-dimensional fluorescence imaging of the brain in moving mice. By utilizing advanced scanning mirrors and ultrafast lasers, the project seeks to capture detailed images of neural activity in real-time, allowing researchers to observe brain function in a more natural, dynamic environment. The approach focuses on overcoming limitations of existing imaging techniques, which often sacrifice speed or resolution. Patients may benefit from insights gained into brain behavior and neural mechanisms that could inform future treatments for neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with neurological conditions or those interested in advancements in brain imaging technologies.
Not a fit: Patients with conditions unrelated to neurological function or those not involved in experimental animal research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding brain function and developing new therapies for neurological disorders.
How similar studies have performed: Other research has shown success with advanced imaging techniques in neuroscience, but this specific approach using MEMS technology for 3D imaging in behaving animals is relatively novel.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Oldham, Kenn R — University of Michigan at Ann Arbor
- Study coordinator: Oldham, Kenn R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.