Hematopoietic stem cell aging and its effects on aging in the body
Official title: Impacts of hematopoietic stem cell aging on distant tissues
Funded at University of California Berkeley · NIH-11436849 · Data updated 2026-11-12
A mouse-based study explores how aging blood stem cells influence aging in other organs and overall health as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | August 15, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $598,837 |
| NIH project number | 1R01AG099235-01A1 |
| Project ID | NIH-11436849 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults over 21 years old with aging-related concerns or diseases may benefit from future translational developments based on these findings.
✕Less likely to help
Direct patient benefits may not occur during the mouse studies, and results may not yet translate to humans.
What this research studies
Researchers will use a mouse model that reverses aging in blood stem cells to study how aging in the blood system affects distant tissues, healthspan, and lifespan. The project will analyze molecular and cellular changes to understand how blood-derived factors influence organ function. This work could reveal targets to improve health during aging and identify how age-related changes in the blood contribute to diseases common in older adults.
Why it matters
Potential benefit: If successful, the research could uncover ways to improve healthy aging and reduce age-related diseases by targeting blood stem cell aging.
How similar studies have gone: Prior work shows blood cell aging can influence another tissues; this study extends those findings with a reversible aging model and healthspan outcomes.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Chen, Danica — University of California Berkeley
- Study coordinator: Chen, Danica
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.