Helping older adults with acute myeloid leukemia and their caregivers make treatment decisions
Official title: A decisional intervention for older adults with acute myeloid leukemia and their caregivers
Funded at University of Rochester · NIH-11045943 · Data updated 2026-11-12
This study is all about helping older adults with acute myeloid leukemia and their caregivers make better decisions about treatment by providing support and information that reflects their values, so they can feel less stressed and improve their quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $678,204 |
| NIH project number | 1R01CA288318-01A1 |
| Project ID | NIH-11045943 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 60 and above who have been diagnosed with acute myeloid leukemia and their caregivers.
✕Less likely to help
Patients who are younger than 60 years old or do not have acute myeloid leukemia may not benefit from this research.
What this research studies
This research focuses on improving the decision-making process for older adults diagnosed with acute myeloid leukemia (AML) and their caregivers. It aims to reduce psychological distress and enhance the quality of life by implementing a shared decision-making approach that incorporates patient values and treatment options. The study will involve a multilevel decisional intervention called UR-GOAL, which has been developed with input from patients and caregivers to ensure it meets their needs. Participants will receive support to understand their disease and treatment choices, helping them make informed decisions quickly.
Why it matters
Potential benefit: If successful, this research could lead to better treatment decisions and improved quality of life for older adults with AML and their caregivers.
How similar studies have gone: Previous research has shown that shared decision-making approaches can significantly reduce distress and improve outcomes for patients with serious illnesses, indicating a promising avenue for this intervention.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Loh, Kah Poh — University of Rochester
- Study coordinator: Loh, Kah Poh
Related research
Other NIH-funded projects on the same topics.
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Decision support program for older adults with acute myeloid leukemia and caregivers
This program offers decision tools and support to help older adults with acute myeloid leukemia and their caregivers understand treatment choices and manage distress.
-
Targeting the SCP4 pathway in acute myeloid leukemia (AML)
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This project tests a therapy that adds a signaling protein, IFN-γ, with donor immune cells to help treat relapsed AML/MDS after a haploidentical stem cell transplant.
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Targeting the protein housekeeping system in adult leukemia
Researchers are testing a new approach to treat acute myeloid leukemia by disrupting how AML cells manage their proteins, with the goal of helping patients live longer and healthier lives.
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Understanding how epigenetic helper proteins drive AML and how to target them
A scientist team is studying how accessory proteins in gene-regulating complexes affect acute myeloid leukemia and whether they can be targeted for safer, more precise therapies.
-
Targeting FLVCR1-enabled choline use in a aggressive AML subtype
A new approach aims to block how a specific leukemia subtype (CG-AML) takes up choline to feed its growth, potentially slowing or stopping the disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.