HBV cure study in people living with HIV or HBV
Official title: Clinical Project
Funded at Johns Hopkins University · NIH-11600304 · Data updated 2026-11-12
Researchers at Johns Hopkins are studying hepatitis B in people with HIV to understand how the virus behaves in blood and how the body responds, with the goal of moving toward a functional cure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 17, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $80,003 |
| NIH project number | 3U19AI188551-02S2 |
| Project ID | NIH-11600304 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are adults living with HIV and/or HBV who have well-characterized clinical histories and available plasma samples suitable for longitudinal HBV marker analysis.
✕Less likely to help
Participants without HIV/HBV coinfection or those with unstable clinical status may not directly benefit from the findings.
What this research studies
This project will analyze blood samples from people living with HIV or HBV to track HBV replication and the body's immune response over time. It will use a broad set of laboratory markers and mathematical models to connect what is seen in plasma with liver disease activity. By comparing different clinical and biological factors, the study aims to identify how HIV therapy and HBV biology influence HBV markers like HBsAg. The work may reveal new targets and timing for therapies that could lead to a functional cure for HBV in the context of HIV coinfection.
Why it matters
Potential benefit: If successful, the research could inform better strategies toward achieving a functional cure for HBV in people living with HIV, potentially improving liver health and longevity.
How similar studies have gone: Previous studies have shown that detailed plasma-based analyses can reveal important dynamics of HBV and host responses, supporting the potential for meaningful insights here.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Thio, Chloe L — Johns Hopkins University
- Study coordinator: Thio, Chloe L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.