Harnessing Platelet-Endothelial Interactions to Deliver Exosomes
Official title: Harnessing Platelet-Endothelial Interactions for Exosome Delivery
Funded at Columbia Univ New York Morningside · NIH-11402592 · Data updated 2026-11-12
Aims to improve delivery of therapeutic exosomes to injured heart and lung tissue using platelet-endothelial interactions in people with acute lung injury or myocardial injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2019 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $735,942 |
| NIH project number | 5R01HL144002-08 |
| Project ID | NIH-11402592 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with acute myocardial infarction or acute pulmonary injury in which exosome-based therapies could be relevant in future trials.
✕Less likely to help
This approach may not benefit patients if delivery improvements do not translate to therapeutic effects or if safety concerns arise.
What this research studies
This project explores a new way to guide therapeutic exosomes to damaged heart and lung tissues by leveraging how platelets interact with the vascular system. Researchers will study how exosomes can be engineered to bind to injured blood vessels and be taken up by cells at sites of injury, potentially increasing their therapeutic impact while reducing off-target distribution. The work involves translating cell-free exosome therapies toward better delivery in models of ischemia/reperfusion injury and acute lung injury, aiming to move closer to human applications. The long-term goal is to improve outcomes for patients with acute myocardial infarction and acute pulmonary injury by more efficiently delivering healing signals.
Why it matters
Potential benefit: If successful, patients with heart or lung injuries could receive more effective exosome therapies with lower doses.
How similar studies have gone: Exosome-based therapies have progressed in early trials, with delivery challenges still being addressed in preclinical work.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Cheng, Ke — Columbia Univ New York Morningside
- Study coordinator: Cheng, Ke
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.