Gut Bacteria That Stop Salmonella Infections
Microbial Metabolites Inhibiting Salmonella Carriage and Disease
This project looks at how natural substances made by gut bacteria might help prevent or treat Salmonella infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11084480 on NIH RePORTER |
What this research studies
Our bodies are home to many bacteria, some of which produce special signals called Diffusible Signal Factors (DSFs). We've found that certain DSFs, like c2-HDA, are very good at stopping Salmonella from growing and causing illness in the gut. Since mammals don't seem to make these specific DSFs, we believe other helpful gut bacteria are responsible for producing them. This work aims to discover which human gut bacteria make these protective substances and understand how they work to control Salmonella. We will also use animal models to further understand these interactions.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical applications would target individuals at risk for or suffering from Salmonella infections.
Not a fit: Patients not affected by bacterial infections, specifically Salmonella, would not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat Salmonella infections by using natural compounds from our gut microbiome.
How similar studies have performed: The concept of gut microbes influencing pathogen behavior is an active area of research, with growing evidence supporting the role of microbial metabolites in host defense.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Altier, Craig — Cornell University
- Study coordinator: Altier, Craig
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.