Gut bacteria fats that drive inflammation in diabetes and heart disease
Gut Microbe-Derived Lipids Shape Chronic Inflammation in Cardiometabolic Disease
This project tests whether a gut microbe-made fat called N-oleoyl serinol can calm the inflammation linked to obesity, type 2 diabetes, and artery disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11325047 on NIH RePORTER |
What this research studies
Researchers found that certain gut microbe-produced lipids are lower in people with obesity-related heart problems and can signal through the host receptor GPR119. The team will use new methods to raise levels of these N-acyl amides and study their effects on inflammation and metabolism. Most work will use preclinical mouse models of obesity, diabetes, and atherosclerosis while linking findings to human blood measurements. The goal is to understand how microbe-to-host signaling might be used to reduce harmful chronic inflammation.
Who could benefit from this research
Good fit: Adults with obesity-related type 2 diabetes or atherosclerotic cardiovascular disease would be the most relevant candidates for related sample collection or future trials.
Not a fit: People without metabolic or cardiovascular disease, such as healthy young adults, are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this work could point to new treatments that reduce chronic inflammation and lower complications from diabetes and heart disease.
How similar studies have performed: Prior studies show gut microbial metabolites can influence host metabolism, but targeting N-acyl amide signaling through GPR119 is a relatively new approach with limited human testing so far.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Brown, Jonathan Mark — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Brown, Jonathan Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.