GPCRs: how receptors get to the cell surface
Official title: GPCR anterograde trafficking
Funded at Augusta University · NIH-11392270 · Data updated 2026-11-12
This grant studies how G protein-coupled receptors (GPCRs) travel from inside cells to the surface, aiming to understand why failures in this process contribute to disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | September 1, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $408,100 |
| NIH project number | 5R35GM136397-07 |
| Project ID | NIH-11392270 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient-involvement study; overall research aims to benefit patients through future drug targeting improvements.
✕Less likely to help
Direct patient benefit is not part of this basic mechanistic project.
What this research studies
GPCRs are critical for many bodily functions and are common drug targets. The project will use advanced lab techniques to map the players that move GPCRs from the ER through the Golgi to the cell surface, and how these carriers are formed and tethered to the membrane. By defining regulators and pathways, the work could reveal new targets to improve GPCR function in diseases where trafficking goes wrong. This research builds on previous findings and employs biochemical, imaging, and live-cell approaches to uncover new mechanisms of GPCR export.
Why it matters
Potential benefit: Understanding GPCR trafficking could lead to new therapeutic strategies for diseases linked to receptor misdelivery.
How similar studies have gone: Previous work has identified key regulators of GPCR trafficking and suggests that further discoveries could enable novel treatments.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Wu, Guangyu — Augusta University
- Study coordinator: Wu, Guangyu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.