GLP-1 medicines and heart/kidney outcomes in adults with type 1 diabetes
Official title: Glucagon Like Peptide-1 Medicine Outcomes in Real World Patients with Type 1 Diabetes
Funded at Adventhealth Orlando · NIH-11455043 · Data updated 2026-11-12
This project looks at whether GLP-1 medicines, already used for weight loss, also help adults with type 1 diabetes by protecting heart and kidney health and how safe they are in real-world use.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Adventhealth Orlando NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $151,816 |
| NIH project number | 1R03DK145927-01A1 |
| Project ID | NIH-11455043 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+) with type 1 diabetes who have obesity or overweight and are considering or currently using GLP-1 medicines.
✕Less likely to help
Patients not using GLP-1 medicines or without cardiovascular/kidney risk factors may experience no direct benefit from this study.
What this research studies
If you have type 1 diabetes and struggle with obesity or cardiovascular risk, this study will use real-world electronic health records to see how GLP-1 medicines affect weight, kidney function, and major health events. Researchers will compare people with type 1 diabetes who are treated with GLP-1 medicines to similar patients not using these medicines, using data from Epic Cosmos. The goal is to understand potential benefits and safety in a large, real-world population over time. Findings could inform whether GLP-1 options might be helpful for cardiorenal health in type 1 diabetes and guide future research and clinical decisions.
Why it matters
Potential benefit: If successful, results may guide safer, more effective use of GLP-1 medicines to protect heart and kidney health in adults with type 1 diabetes.
How similar studies have gone: prior studies in type 2 diabetes show benefits of GLP-1 medicines, but data in type 1 diabetes are limited; this study explores a new application in T1D using real-world data.
Where this research is happening
-
Adventhealth Orlando
Orlando, United States Active
Researchers
- Principal investigator: Love, Kaitlin M — Adventhealth Orlando
- Study coordinator: Love, Kaitlin M
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.