Global Sjogren's next-generation patient biobank and data resource
Sjogren's International Collaborative Clinical Alliance Next Generation Studies (SICCA-NextGen)
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11472801
This project collects blood and salivary gland samples plus advanced genetic and cell-level data from people with Sjogren's to improve understanding of how the disease differs across patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11472801 on ClinicalTrials.gov |
What this research studies
If you join, the project builds on a large international registry and asks you to give blood and, in some cases, a small salivary gland tissue sample and medical information. Researchers analyze these samples using single-cell and bulk RNA sequencing, DNA methylation profiling, exome sequencing, and immune receptor (BCR/TCR) sequencing to map immune cells and gene activity. The team has already generated single-cell data from hundreds of blood and salivary gland samples and is expanding epigenetic and exome analyses across thousands of gland samples. Study data and genetic resources are shared through public repositories to help other researchers search for biomarkers and disease subtypes.
Who could benefit from this research
Good fit: Ideal candidates are adults with diagnosed or suspected Sjogren's who are willing to provide blood and sometimes a small salivary gland tissue sample and share medical history.
Not a fit: People without Sjogren's, those unwilling or unable to provide biological samples or medical data, and those expecting immediate treatment benefit are unlikely to gain direct clinical benefit from participating.
Why it matters
Potential benefit: This work could help identify blood or tissue biomarkers, define Sjogren's subtypes, and guide more personalized diagnosis and treatment in the future.
How similar studies have performed: Earlier SICCA work successfully created a large international biobank and identified genetic and epigenetic patterns in Sjogren's, and the current single-cell and epigenetic work builds on those validated findings.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHIBOSKI, CAROLINE HELENE — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: SHIBOSKI, CAROLINE HELENE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases