Genomic patterns and features in cerebral palsy
Official title: Characterizing the spectrum of genomic and phenotypic variation in cerebral palsy
Funded at Geisinger Clinic · NIH-11365911 · Data updated 2026-11-12
A study to understand how rare and common genetic differences relate to cerebral palsy in children and adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Geisinger Clinic NIH-funded |
| Lab location | 1 site (Danville, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $672,991 |
| NIH project number | 5R01HD104938-05 |
| Project ID | NIH-11365911 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with cerebral palsy who have or have not had genetic testing, including both children and adults.
✕Less likely to help
People with CP for whom genetic causes are unlikely or who do not consent to genetic analyses may not benefit.
What this research studies
This project looks at the genetic makeup of people with cerebral palsy to see how rare and common genetic variants contribute to the condition. Researchers will analyze data from two groups: a pediatric cohort undergoing exome sequencing and an adult cohort with rich genetic and health record information. By linking genomic findings with detailed clinical and imaging data, the study aims to describe how genetic differences relate to the changes seen in CP. The goal is to build a clearer map of why CP occurs and why people with CP experience different symptoms.
Why it matters
Potential benefit: It could lead to better understanding of CP causes and pave the way for more precise diagnoses and personalized management.
How similar studies have gone: Previous work in developmental brain disorders has shown that both rare and common genetic variants contribute to phenotypes, supporting this approach for CP.
Where this research is happening
-
Geisinger Clinic
Danville, United States Active
Researchers
- Principal investigator: Myers, Scott — Geisinger Clinic
- Study coordinator: Myers, Scott
Related research
Other NIH-funded projects on the same topics.
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-
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This research looks at how hindfoot problems in adults with cerebral palsy behave over time after childhood surgeries and what factors influence their lasting function.
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Dynamic Brain Imaging of Cerebral Palsy Gait
This project uses advanced brain and spinal imaging to understand how cerebral palsy affects the way young people plan and control their leg movements during walking.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.