Genome-scale measurements of how pathogen metabolism changes during infection
Official title: Developing genome-scale fluxomics to uncover metabolic reprogramming in human pathogens during infection
Funded at Dartmouth College · NIH-11435242 · Data updated 2026-11-12
A research program will map how metabolic reaction rates in human pathogens change when they face the host, with the aim of finding new ways to curb virulence.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | August 4, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $458,854 |
| NIH project number | 1DP2AI200956-01 |
| Project ID | NIH-11435242 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient group; this is a basic science project on pathogen metabolism.
✕Less likely to help
Direct patient benefit may be indirect and long-term through better therapies.
What this research studies
The project aims to quantify metabolic fluxes across a pathogen’s entire network during infection, moving beyond static omics data. It will develop genome-scale fluxomics tools and automate data processing so scientists can routinely measure dynamic metabolic changes. This could reveal new metabolic targets for anti-virulence strategies and improve our understanding of how pathogens adapt to hostile host environments.
Why it matters
Potential benefit: If successful, the work could identify new metabolic targets to weaken pathogens and guide development of anti-virulence therapies.
How similar studies have gone: Previous fluxomics approaches were limited to small networks; this project seeks to scale up to genome-wide measurements, representing a novel expansion.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Liao, Chen — Dartmouth College
- Study coordinator: Liao, Chen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.