Genetics of hidradenitis suppurativa in diverse populations
Official title: Whole genome sequencing analysis of hidradenitis suppurativa
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-11195106 · Data updated 2026-11-12
Researchers will use whole-genome sequencing to find genetic differences that might explain why hidradenitis suppurativa affects some people, especially African American and Hispanic/Latino patients, more severely.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $614,933 |
| NIH project number | 5R01AR083553-02 |
| Project ID | NIH-11195106 on NIH RePORTER |
Who could benefit from this research
✓Could help
People diagnosed with hidradenitis suppurativa who can provide a DNA sample or allow access to their genetic data, especially those of African American or Hispanic/Latino ancestry, are ideal candidates.
✕Less likely to help
People without HS or those seeking immediate changes to their medical care are unlikely to get direct clinical benefit from participating in this genetic research.
What this research studies
If you join this project, researchers will use whole-genome sequencing to scan all of your DNA for genetic changes linked to hidradenitis suppurativa (HS). They will compare genetic data from African American, Hispanic/Latino, and White patients and look for differences that might help explain racial and sex-related gaps in who gets HS and how severe it is. The team will combine new sequencing with existing resources such as the All of Us WGS data to increase the number of people studied and search for both rare and common variants. Results aim to point to biological pathways behind painful nodules, abscesses, and scarring and to guide future personalized approaches.
Why it matters
Potential benefit: If successful, this work could clarify genetic reasons for disparities in HS and eventually help guide more targeted prevention or treatment strategies.
How similar studies have gone: Only one prior genome-wide association study for HS has been published, so whole-genome sequencing in diverse groups is relatively novel though genetics has been implicated in HS risk.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Mi, Qing-Sheng — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Mi, Qing-Sheng
Related research
Other NIH-funded projects on the same topics.
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Anti-CD38 immunotherapy for severe hidradenitis suppurativa
A new treatment using anti-CD38 therapy is being tested for people with severe hidradenitis suppurativa who have not responded to prior therapies.
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Botulinum toxin blocks nerve signals to immune cells to treat hidradenitis suppurativa
This NIH grant tests a new approach to hidradenitis suppurativa by using botulinum toxin to interrupt nerve signals that may drive skin inflammation in patients.
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Precision therapies for hidradenitis suppurativa using AI
A doctor-researcher team at UC San Francisco is using advanced computer methods to find personalized drug options to treat hidradenitis suppurativa.
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Injectable Hydrogel for HS: a localized therapy to ease painful skin disease
A new baricitinib hydrogel is being developed to deliver pain relief and reduce inflammation directly in hidradenitis suppurativa (HS) lesions, potentially lowering systemic side effects.
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Whole-genome sequencing to understand hidradenitis suppurativa in diverse groups
Researchers will study the genetic factors that contribute to hidradenitis suppurativa, especially in African American, Hispanic/Latino, and White patients, to better understand why some people are more affected.
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Understanding the Genes Behind Hidradenitis Suppurativa in teens and young adults
A study to find genetic factors that contribute to hidradenitis suppurativa (HS), a painful skin condition that often starts in adolescence and affects many Black individuals.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.