Genetics of hidradenitis suppurativa in diverse populations
Whole genome sequencing analysis of hidradenitis suppurativa
Researchers will use whole-genome sequencing to find genetic differences that might explain why hidradenitis suppurativa affects some people, especially African American and Hispanic/Latino patients, more severely.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11195106 on NIH RePORTER |
What this research studies
If you join this project, researchers will use whole-genome sequencing to scan all of your DNA for genetic changes linked to hidradenitis suppurativa (HS). They will compare genetic data from African American, Hispanic/Latino, and White patients and look for differences that might help explain racial and sex-related gaps in who gets HS and how severe it is. The team will combine new sequencing with existing resources such as the All of Us WGS data to increase the number of people studied and search for both rare and common variants. Results aim to point to biological pathways behind painful nodules, abscesses, and scarring and to guide future personalized approaches.
Who could benefit from this research
Good fit: People diagnosed with hidradenitis suppurativa who can provide a DNA sample or allow access to their genetic data, especially those of African American or Hispanic/Latino ancestry, are ideal candidates.
Not a fit: People without HS or those seeking immediate changes to their medical care are unlikely to get direct clinical benefit from participating in this genetic research.
Why it matters
Potential benefit: If successful, this work could clarify genetic reasons for disparities in HS and eventually help guide more targeted prevention or treatment strategies.
How similar studies have performed: Only one prior genome-wide association study for HS has been published, so whole-genome sequencing in diverse groups is relatively novel though genetics has been implicated in HS risk.
Where this research is happening
East Lansing, United States
- Henry Ford Health + Michigan State University Health Sciences — East Lansing, United States (Active)
Researchers
- Principal investigator: Mi, Qing-Sheng — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Mi, Qing-Sheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.