Genetics and systems biology core for autoimmune diseases
Immunogenomics and Systems Biology Core
This project builds a shared data and analysis hub that combines patient genetic, single-cell, and tissue-mapping information to better understand and classify autoimmune diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11306981 on NIH RePORTER |
What this research studies
As a patient, I would understand that this core collects and harmonizes many kinds of patient data — including genetics, epigenetics, single-cell and spatial sequencing — into standardized datasets. The team runs vetted, scalable analysis pipelines and advanced modeling to uncover molecular patterns that explain differences in disease course and treatment response. They plan to build disease-specific molecular roadmaps and identify biomarkers that could guide future treatments and trials. The curated data and methods will be shared across the AMP AIM network to help other researchers move faster toward patient-focused studies.
Who could benefit from this research
Good fit: Ideal candidates are people with autoimmune conditions (for example atopic dermatitis and related disorders) who are enrolled or eligible for AMP AIM network studies and willing to provide clinical information or biological samples.
Not a fit: People without autoimmune disease or those not enrolled in the AMP AIM network are unlikely to be directly affected or receive immediate benefit from this core.
Why it matters
Potential benefit: If successful, this could speed discovery of disease mechanisms and biomarkers that lead to more precise treatments and better matching of patients to therapies or trials.
How similar studies have performed: Other multi-omics and single-cell projects have already revealed new disease mechanisms and biomarkers, though integrating single-cell and spatial data across many patients at scale is still an emerging area.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Gudjonsson, Johann Eli — University of Michigan at Ann Arbor
- Study coordinator: Gudjonsson, Johann Eli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.