Genetics and protein changes linked to adult ARDS
Genomic/Genetic and Proteome
Researchers are using genetic and protein information to find biological changes tied to severe acute respiratory distress in adults.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11193827 on NIH RePORTER |
What this research studies
This project combines analysis of large DNA, RNA, and methylation datasets with lab studies of human cells and proteins to understand ARDS. Scientists will search existing patient genomic datasets for DNA variants linked to ARDS risk and severity, then create genome-edited human endothelial cell lines carrying those mutations to test their effects. They will use mass spectrometry to detect protein modifications, model how mutations change protein structure and interactions, and validate key interactions with laboratory techniques. The core will also produce recombinant proteins with specific mutations to study how those changes affect function.
Who could benefit from this research
Good fit: Adults who have had ARDS, are at high risk for ARDS, or who can provide clinical data or biospecimens for genetic or proteomic analysis would be the most relevant candidates.
Not a fit: Children, people without ARDS and those unable or unwilling to provide samples or clinical data are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could reveal new biomarkers or drug targets to predict, prevent, or better treat severe ARDS in adults.
How similar studies have performed: Previous genetic and proteomic studies have found some ARDS-related signals, but combining large-scale human data with genome-edited human cell models and protein structural validation is relatively new.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Ellis, Nathan a. — University of Florida
- Study coordinator: Ellis, Nathan a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.