Genetic screening of embryos to help make informed decisions about health risks.
Polygenic Embryo Screening: Towards Informed Decision-Making
['FUNDING_R01'] · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · NIH-10813733
This study is looking at a new way to check embryos for genetic risks related to common traits and diseases, helping parents-to-be and doctors make better choices about which embryos to use for pregnancy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (nih funded) |
| Locations | 1 site (MANHASSET, UNITED STATES) |
| Trial ID | NIH-10813733 on ClinicalTrials.gov |
What this research studies
This research investigates the use of polygenic embryo screening (PES) to assess the genetic risks associated with common traits and diseases in embryos. By analyzing genome-wide genotypes from single-cell samples, the study aims to provide insights into the potential health outcomes of embryos before implantation. It also explores the ethical implications and the perspectives of healthcare providers regarding the use of PES in clinical settings. The goal is to equip clinicians and patients with the necessary information to make informed decisions about embryo selection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals or couples undergoing in vitro fertilization (IVF) who are interested in genetic screening of their embryos.
Not a fit: Patients who are not undergoing IVF or who do not have concerns about genetic risks in their embryos may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enable prospective parents to make better-informed choices regarding embryo selection, potentially reducing the risk of hereditary diseases.
How similar studies have performed: While the concept of polygenic embryo screening is relatively novel, there has been growing interest and preliminary research indicating its potential, though comprehensive empirical data is still lacking.
Where this research is happening
MANHASSET, UNITED STATES
- FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH — MANHASSET, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LENCZ, TODD — FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
- Study coordinator: LENCZ, TODD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Mental health disorders, Psychiatric Disease, Psychiatric Disorder, psychological disorder, Mental disorders