Genetic interactions shaping stem cell behavior in fruit fly intestines
Official title: Genetic interactions among targets of master regulator genes as drivers of complex behavior in Drosophila intestinal stem cells
Funded at California State University Northridge · NIH-11384155 · Data updated 2026-11-12
Scientists study how teamed-up gene targets of master regulators influence how intestinal stem cells grow and differentiate in fruit flies, with the goal of guiding regenerative strategies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Northridge NIH-funded |
| Lab location | 1 site (Northridge, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $147,500 |
| NIH project number | 5R16GM149452-04 |
| Project ID | NIH-11384155 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to a specific patient population in this basic science grant.
✕Less likely to help
This basic science grant does not enroll patients or provide direct patient care.
What this research studies
This project uses the fruit fly model to map how downstream gene targets of master regulator genes coordinate intestinal stem cell proliferation, self-renewal, and differentiation. Researchers will manipulate specific gene targets alone and together in intestinal stem cells and observe effects on tissue balance using microscopy and other analyses. The work explores how combinations of gene interactions drive complex cell behavior, aiming to identify more precise targets for regenerative medicine. Findings could illuminate basic biology applicable to stem cell therapies in humans.
Why it matters
Potential benefit: Improved understanding of how to modulate stem cell behavior could inform future regenerative therapies.
How similar studies have gone: Previous work shows that single gene targets have strong effects; this project tests combined targets to reveal more nuanced control.
Where this research is happening
-
California State University Northridge
Northridge, United States Active
Researchers
- Principal investigator: Loza Coll, Mariano a — California State University Northridge
- Study coordinator: Loza Coll, Mariano a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.