Structural dynamics of G protein signaling in health and disease
Official title: Structural dynamics and energy landscapes of G protein signaling
Funded at California State University Northridge · NIH-11349698 · Data updated 2026-11-12
A patient-friendly look at how GPCR signaling works in the body and why it matters for many conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Northridge NIH-funded |
| Lab location | 1 site (Northridge, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $147,500 |
| NIH project number | 5R16GM153621-03 |
| Project ID | NIH-11349698 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with conditions influenced by GPCR signaling, such as metabolic, nervous, cardiovascular, or immune disorders, may benefit from future therapies informed by this research.
✕Less likely to help
Participants directly involved in this grant are not specified as recruiting yet; future trials would depend on subsequent developments.
What this research studies
This project studies how GPCRs, the cell’s signal receivers, change shape and interact with other proteins to control multiple cellular pathways. By mapping energy landscapes and dynamic signaling patterns, researchers aim to understand why these receptors behave differently in various tissues and diseases. The findings could help guide development of therapies that target GPCR signaling more precisely. If successful, this work may inform future treatments for metabolic, nervous, cardiovascular, and immune-related conditions.
Why it matters
Potential benefit: New insights into GPCR signaling could lead to smarter, more effective therapies for a wide range of diseases.
How similar studies have gone: Previous work has shown GPCR signaling is complex and context-dependent, with progress in understanding receptor dynamics.
Where this research is happening
-
California State University Northridge
Northridge, United States Active
Researchers
- Principal investigator: Abrol, Ravinder — California State University Northridge
- Study coordinator: Abrol, Ravinder
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.