Genetic factors behind how cells regulate stress responses after transcription
Official title: The Genetic Basis of Variation in Post-Transcriptional Regulation of Stress Defense
Funded at University of Arkansas at Fayetteville · NIH-11260020 · Data updated 2026-11-12
This grant studies how cells decide what to do after making RNA when they’re stressed, using yeast to understand why people vary in stress tolerance and vulnerability.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arkansas at Fayetteville NIH-funded |
| Lab location | 1 site (Fayetteville, United States) |
| Project start | August 1, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $401,254 |
| NIH project number | 1R35GM161393-01 |
| Project ID | NIH-11260020 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with conditions tied to stress response dysregulation, or those who could benefit from future therapies targeting post-transcriptional regulation.
✕Less likely to help
Individuals not connected to stress-related conditions or without access to related future trials may see limited direct relevance.
What this research studies
Researchers will use baker’s yeast to map how genetic differences affect post-transcriptional regulation during stress. They’ll apply high-throughput genetic screens and quantitative analyses to link natural genetic variation to how cells control stress defenses after RNA is made. The work aims to build a mechanistic picture of how post-transcriptional regulation shapes resilience or susceptibility to diseases related to stress responses. The findings could illuminate why some people are more prone to cancer or neurodegenerative conditions based on their regulatory biology. The project spans five years and relies on advanced genetic and genomic tools to dissect these regulatory networks.
Why it matters
Potential benefit: Understanding these regulatory pathways could lead to new ideas for predicting and improving stress resilience in humans.
How similar studies have gone: Previous work shows that regulatory variation can influence stress responses, and this study extends those insights using high-throughput yeast genetics.
Where this research is happening
-
University of Arkansas at Fayetteville
Fayetteville, United States Active
Researchers
- Principal investigator: Lewis, Jeffrey a — University of Arkansas at Fayetteville
- Study coordinator: Lewis, Jeffrey a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.