Genetic causes of depression in South Korean adults
Identifying the genetic causes of depression in a deeply phenotyped population from South Korea
['FUNDING_U01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11132893
This project looks for genetic differences linked to major depression in deeply studied adults from South Korea.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11132893 on ClinicalTrials.gov |
What this research studies
You would be asked to share detailed information about your mood, medical history, and life experiences and to provide a DNA sample. Researchers will combine these clinical and genetic data from many participants to create the largest East Asian dataset for depression genetics. They will use advanced statistical methods, including Bayesian approaches, to find genetic variants that relate to different features of depression and to account for environmental risks. Findings will be compared with results from other populations to find shared and population-specific risk factors.
Who could benefit from this research
Good fit: Ideal participants are adults of East Asian ancestry, especially people from South Korea with a history of major depressive disorder who can provide clinical information and a DNA sample.
Not a fit: People under 21, those not of East Asian ancestry, or anyone unwilling to provide genetic or clinical information would not be directly eligible or helped by this project.
Why it matters
Potential benefit: If successful, this work could reveal biological causes of depression that help predict risk, improve diagnosis, or point to new treatment targets.
How similar studies have performed: Large genetic studies have found risk genes for other psychiatric disorders and for depression in mainly European groups, but similarly large, detailed work in East Asian populations is newer and less complete.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FLINT, JONATHAN — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: FLINT, JONATHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anxiety Disorders