Genetic and cellular drivers of coronary artery disease
Multimodal genetic regulatory architecture of coronary artery disease
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-11123500
Learning how genetic differences and changes in artery cells contribute to coronary artery disease in people with or at risk for atherosclerotic heart disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11123500 on ClinicalTrials.gov |
What this research studies
This project uses donated coronary artery tissues and clinical data from people like you to study genes and cell behavior in atherosclerosis. Researchers will use single-cell and single-nucleus methods to map gene expression and chromatin accessibility in individual artery cells, focusing on smooth muscle and other cell types that change during disease. They will combine data from a large, ancestrally diverse biobank and integrate genetic maps (QTLs) to link genetic variants to specific cell states. The aim is to identify the causal genes and regulatory elements that drive disease so future tests or treatments can target them.
Who could benefit from this research
Good fit: Ideal candidates would be adults with coronary artery disease or people undergoing cardiac procedures who can donate tissue samples or allow access to clinical data.
Not a fit: People not affected by coronary artery disease or those unwilling/unable to donate tissue or data are unlikely to benefit directly from participating.
Why it matters
Potential benefit: If successful, this work could point to specific genes and cell types to target for new therapies or better risk prediction for coronary artery disease.
How similar studies have performed: Related single-cell genomics studies have already revealed new cell states and regulatory elements in atherosclerosis, but proving causal mechanisms and translating them into therapies remains largely unachieved.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLER, CLINT L — UNIVERSITY OF VIRGINIA
- Study coordinator: MILLER, CLINT L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease