Forecasting when seizures might occur in people with epilepsy
Official title: Personalized Seizure Forecasting: A Precision Medicine Approach
Funded at Yale University · NIH-11000075 · Data updated 2026-11-12
This study is looking to help people with epilepsy by finding a way to predict seizures using changes in saliva and brain activity, so that patients and their families can better plan their daily lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,319,282 |
| NIH project number | 1R01NS132121-01A1 |
| Project ID | NIH-11000075 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with epilepsy who experience recurrent seizures.
✕Less likely to help
Patients who do not have epilepsy or those whose seizures are already well-controlled may not benefit from this research.
What this research studies
This research aims to develop a method for predicting seizures in individuals with epilepsy by analyzing biochemical changes in saliva and electrical activity in the brain. By using a Responsive Neurostimulation (RNS®) System, the study will explore the relationship between these biochemical markers and the likelihood of seizures. The goal is to create a forecasting tool that allows patients and their families to anticipate seizures, improving their ability to plan and manage daily activities. This innovative approach could significantly enhance the quality of life for those affected by epilepsy.
Why it matters
Potential benefit: If successful, this research could provide patients with the ability to predict and prepare for seizures, potentially reducing their impact on daily life.
How similar studies have gone: Previous research has shown promise in using similar predictive approaches for other medical conditions, suggesting potential success in this novel application for epilepsy.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Zaveri, Hitten P — Yale University
- Study coordinator: Zaveri, Hitten P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.