Finding ways to overcome antibiotic resistance in a common bacterial infection
Combating Fosfomycin Resistance in Methicillin-Resistant Staphylococcus aureus
This study is looking for better ways to treat infections caused by tough bacteria like MRSA by combining current antibiotics with other agents to make them work better, which could help patients who have infections that are hard to treat.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama in Tuscaloosa NIH-funded |
| Lab location | 1 site (Tuscaloosa, United States) |
| Project ID | NIH-10580471 on NIH RePORTER |
What this research studies
This research focuses on addressing the growing problem of antibiotic resistance, particularly in methicillin-resistant Staphylococcus aureus (MRSA). The team aims to develop new treatment strategies by combining existing antibiotics with agents that can neutralize resistance mechanisms. By studying how certain enzymes in bacteria deactivate antibiotics, the researchers hope to enhance the effectiveness of fosfomycin, a broad-spectrum antibiotic. This approach could help preserve newer antibiotics for future use and improve treatment outcomes for patients with resistant infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with infections caused by methicillin-resistant Staphylococcus aureus (MRSA) or other multidrug-resistant bacteria.
Not a fit: Patients with infections caused by bacteria that are not resistant to antibiotics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from antibiotic-resistant bacterial infections.
How similar studies have performed: Previous research has shown promise in using combination therapies to combat antibiotic resistance, indicating that this approach may be effective.
Where this research is happening
Tuscaloosa, United States
- University of Alabama in Tuscaloosa — Tuscaloosa, United States (Active)
Researchers
- Principal investigator: Thompson, Matthew Kyle — University of Alabama in Tuscaloosa
- Study coordinator: Thompson, Matthew Kyle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.